Lunatic Fringe, Manic Fringe, and Radical Fringe Recognize Similar Specificity Determinants in O-Fucosylated Epidermal Growth Factor-like Repeats
نویسندگان
چکیده
منابع مشابه
Zebrafish lunatic fringe demarcates segmental boundaries
Cell interactions involving Notch signaling are required for the demarcation of tissue boundaries in both invertebrate and vertebrate development. Members of the Fringe gene family encode beta-1,3 N-acetyl-glucosaminyltransferases that function to refine the spatial localization of Notch-receptor signaling to tissue boundaries. In this paper we describe the isolation and characterization of the...
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High-resolution TEM is well-suited to characterizing nanocrystals, where lattice fringes serve as a source of structural information [1, 2]. For example, 3D lattice parameters can be measured from 2D lattice fringe images taken at as few as two different specimen orientations [3-6]. Recent work has shown that lattice fringe-visibility maps, a thin-specimen extension of bend-contour and channeli...
متن کاملView from the Fringe of the Fringe
Formal analysis remains outside the mainstream of system design practice. Interactive methods and tools are regarded by some to be on the margin of useful research in this area. Although it may seem relatively academic to some, it is vital that this the so-called “theorem proving approach” continue to be as vigorously explored as approaches favoring highly automated reasoning. Design derivation...
متن کاملLunatic Fringe-mediated Notch signaling is required for lung alveogenesis.
Distal lung development occurs through coordinated induction of myofibroblasts, epithelial cells, and capillaries. Lunatic Fringe (Lfng) is a beta(1-3) N-acetylglucosamine transferase that modifies Notch receptors to facilitate their activation by Delta-like (Dll1/4) ligands. Lfng is expressed in the distal lung during saccular development, and deletion of this gene impairs myofibroblast differ...
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T cells differentiate from bone marrow-derived stem cells by expressing developmental stage-specific genes. We here searched arrays of genes that are highly expressed in mature CD4-CD8+ (CD8 single-positive (SP)) T cells but little in CD4+CD8+ (double-positive (DP)) cells by cDNA subtraction. Lunatic fringe (Lfng), a modulator of Notch signaling, was identified to be little expressed in DP cell...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2005
ISSN: 0021-9258
DOI: 10.1074/jbc.m509552200